Endocrine Abstracts

A 41-year old lady with hypothyroidism for 20 years attended the endocrinology clinic for persistently raised TSH levels despite high dose levothyroxine. Past medical problems – depression, psoriasis, obesity, cholecystectomy. Her hypothyroidism was well-controlled until 2016 but since then, her TSH concentration had risen significantly to >100 mU/l with normal free T4. Levothyroxine had been increased in steps to 200 mcg/day. Despite the increased dose, the TSH concentra...

Our endocrinology department had been looking after a patient with Graves’ disease since 2007. At this time, she was 17 years old (TSH <0.03 mIU/l, T4 62.6 pmol/l). Carbimazole was prescribed but she was non-compliant with medications and clinic appointments. Her background history included DiGeorge Syndrome (22q11 deletion) manifesting with a bicuspid aortic valve, primary hypoparathyroidism and chronic constipation. She was seen in October 2011 and carbimazole incre...